How Benchling secured multi-tenant AI agents with Amazon Bedrock AgentCore

When Benchling needed to run AI agent-generated scientific code across thousands of life sciences tenants, their security team found that traditional sandboxing wasn’t enough. Today, this architecture processes more than 600 code execution sessions per day across more than 250 tenants per week with zero security incidents. Standard network controls block HTTP, restrict egress ports, and limit outbound connections. However, DNS resolution is often still permitted, and even when system defaults restrict it, you may not have visibility into or control over those restrictions. This is the challenge Benchling faced when deploying AI agents across thousands of life sciences tenants. Their security team needed full control over network isolation beyond the system defaults to meet their threat model for executing untrusted code at scale.

In this post, we show how Benchling built a defense-in-depth security architecture to run AI agent-generated scientific code across thousands of life sciences tenants. Amazon Bedrock AgentCore is a platform to build, connect, and optimize agents at scale, with any framework or model. Benchling uses AgentCore Code Interpreter, a capability of Amazon Bedrock AgentCore, in Amazon Virtual Private Cloud (VPC) mode. This approach combines account-level isolation, Amazon Route 53 Resolver DNS Firewall, and VPC endpoint policies to help prevent data exfiltration while enforcing per-job data access controls.